Is the fermentation industry also using membrane technology？

Is the fermentation industry also using membrane technology？

The main separation techniques commonly used in the fermentation industry are precipitation, salting-out, solvent extraction and adsorption. In addition, bacteria separation, concentration, decolorization, crystallization and so on are also required. Compared with the traditional process, the integrated membrane separation system of Jiuwu ceramic membrane has the advantages of high separation precision, high quality of filtrate, high throughput filtration, high product yield, less waste water and low cleaning frequency. The desalination and pre-concentration of the target products can be achieved without the addition of additives, which has been successfully applied to the biological fermentation industries such as glutamic acid, lysine, threonine, tryptophan, citric acid, itaconic acid, vitamin C and so on.

As a new technology, membrane separation can not produce secondary pollution because of its no phase change in the separation process, and it has the function of biofilm concentration and enrichment, convenient operation, compact structure, low maintenance cost and easy automation. Therefore, it has been applied in the post-treatment of many kinds of fermentation products. The treatment of fermentation broth by membrane technology can remove all kinds of impurities which are different from the molecular weight of the product according to the molecular weight of the material, and improve the quality of the fermentation broth, which is beneficial to the subsequent process and to the improvement of the purity and yield of the product. Reduce solvent consumption, reduce energy consumption.

Antibiotic production process can be divided into four processes: fermentation, filtration, concentration and drying. At present, membrane technology is mainly used in the clarification of antibiotic fermentation broth, the concentration and desalination of products and the concentration of antibiotics in waste water. The antibiotic raw liquid produced by fermentation method contains 4% biological residue, indefinite salt and about 0.1% / 0.2% antibiotics. Traditional solvent extraction was used to separate from fermentation broth, and then vacuum evaporation was carried out to obtain antibiotics. However, the purification and concentration of antibiotics by this method has many disadvantages, such as large amount of organic solvent, high energy consumption of evaporation and concentration, poor operating environment, etc. Nanofiltration membrane can be recovered and purified in two ways. Antibiotics: one is extraction with solvent, then concentrated with nanofiltration membrane, this process can save 80% cost because the solvent can be recycled; The other is using membrane concentration and solvent extraction, this method can greatly improve the production capacity of extraction equipment and reduce the amount of solvent. In addition to nanofiltration membrane, ultrafiltration and reverse osmosis are widely used in antibiotic post-treatment. The microfiltration membrane was used to remove the mycelium from penicillin fermentation broth, and the recovery of penicillin could reach 98%. The concentrated lincomycin fermentation broth was purified by the combination of ultrafiltration and nanofiltration, which greatly saved the solvent and energy, shortened and optimized the concentration of lincomycin fermentation broth. The traditional process is used to improve the yield and quality of the product. The protein and other macromolecular impurities can be removed by using ultrafiltration membrane separation technology in penicillin extraction process, and the emulsifying phenomenon during extraction can be eliminated, and the yield of extraction process can be improved. The fermentation filtrates of kanamycin sulfate and cephalosporin were treated by suitable ultrafiltration membrane, and satisfactory results were obtained.